Rabu, 15 Februari 2012

DRUGS WITH ANTICHOLINERGIC PROPERTIES

MEDICATIONS WITH SIGNIFICANT ANTICHOLINERGIC PROPERTIES
Therapeutic Categories (Drug List*)
Potential Adverse Consequences
Antihistamines 
• chlorpheniramine, cyproheptadine, diphenhydramine, hydroxyzine
Blood pressure, increased 
Breathing difficulty, changes
 
Clumsiness or unsteadiness
 
Convulsions
 
Digestive system changes, e.g.,
• Bloating 
• Bowel motility, decreased
 
• Constipation
 
• Ileus, paralytic/adynamic
 
• Nausea or vomiting
 
• Swallowing difficulty with dry mouth
Mental status/behavior changes, e.g.,
• Distress, excitement, nervousness
• Attention, impaired
 
• Cognitive decline
 
• Confusion/disorientation
 
• Hallucinations
 
• Memory loss
 
• Restlessness or irritability
Delirium 
Dizziness or Drowsiness
 
Fever
 
Headache
 
Heart rate, increased
 
Lethargy, fatigue
 
Mucous membrane dryness: mouth, nose
 
Muscle weakness, severe
 
Speech, slurring
 
Skin, changes
• Dryness 
• Sweating, decreased
 
• Flushing
 
• Warmth, excessive
Vision impairment, changes in acuity
• Blurring 
• Glaucoma, worsening
 
• Eye pain
 
• Light sensitivity
Urinary retention or difficulty

By Akshaya Srikanth, Pharm.D Intern, India
Antidepressants 
• amoxapine, amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, paroxetine
Antipsychotics 
• chlorpromazine, clozapine, olanzapine, thioridazine
Antivertigo 
• meclizine, scopolamine
Cardiovascular 
• furosemide, digoxin, nifedipine, disopyramide
Gastrointestinal 
• Antidiarrheal: diphenoxylate atropine
 
• Antispasmodics: belladonna, clidinium, chlordiazepoxide, dicyclomine, hyoscyamine, propantheline
 
• Antiulcer: cimetidine, ranitidine
Muscle Relaxants 
• cyclobenzaprine, dantrolene, orphenadrine
Parkinsonism 
• amantadine, benztropine, biperiden, trihexyphenidyl
Urinary Incontinence 
• oxybutynin, propantheline, solifenacin, tolterodine, trospium












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