Selasa, 31 Januari 2012

Flesh- Eating Bug Kills In Hours

Flesh-eating disease is the medical equivalent of being struck by lightning: it’s extremely rare and very tragic.

And the fact that it moves at breakneck speed, capable of killing a healthy person in as little as 12 hours, makes it an especially frightening and intriguing disease.
“You don’t have the luxury of waiting around a few days to find out what’s going on,” says Dr. Michael Gardam, an infectious disease specialist at University Health Network in Toronto. “You’ve got to jump on it right away.”
The tricky thing about this bacterial infection is that typical symptoms include skin infection and flu-like aches and pains, so some patients and even doctors may not recognize what they’re dealing with until it’s too late.
The disease recently sparked headlines when a Mississauga woman, Debbie Sebesta, died from it last Wednesday. Three days earlier, the otherwise healthy woman was complaining of a bruise and pain in her leg. Within hours, flu-like symptoms such as chills and vomiting had set in and were worsening by the minute.
After being rushed to hospital, Sebesta underwent surgery to remove large part of her leg, which was infected with necrotizing fasciitis, often called flesh-eating disease because it kills muscle and skin as it spreads through the tissue.
Cases such as Sebesta’s are “the tip of the iceberg,” says Dr. Neil Rau, an infectious diseases specialist with a private practice in Oakville, who uses the analogy of being struck by lightning to highlight their rarity.
A few years ago, one of his patients cut her index finger while peeling an apple and became infected. Days later, the infection spread up her arm, to the armpit and across the chest. She was operated on, but later succumbed to the disease.
Such tragedies are rare, says Rau, noting that even in severe cases of the disease, most people don’t die. Such was the case in the winter of 1994 when Lucien Bouchard, then-leader of the Bloc Québécois, was forced to have his leg amputated because of the illness.
“For every terrible case we hear about, there are millions of people who have no symptoms or only mild symptoms,” says Rau.
According to Health Canada, there are between 90 and 200 cases of necrotizing fasciitis each year, about 20 to 30 per cent of which are fatal.
Infection is caused by different strains of bacteria, including group A streptococcus (GAS), a bacterium often found in the throat and on the skin of healthy people. Most people who carry GAS have no symptoms of illness and most infections are relatively mild illnesses, such as strep throat.
Infection often develops when bacteria enters the body, usually through a minor cut or scrape. In rare cases, that infection will spread and release harmful toxins.
Among the telltale signs that a person may have the disease is a small cut that may not look so bad but is causing immense pain, a skin infection that is spreading and flu-like symptoms, such as vomiting, diarrhea and chills.
One of the cardinal features of flesh-eating disease, says Gardam is that “the pain is more than you’d expect from what you’re looking at.”

Eight limbed boy celebrating after surgery to remove parasitic twin

STORY: These incredible pictures show the remarkable work of surgeons who removed a parasitic twin from a boy dubbed, 'The Eight-Limbed Boy'.
Deepak Paswaan was taunted and called a 'devil' and 'freak' as he was born with a parasitic twin jutting from his stomach.
Born in Bihar, India, Deepak spent his young life carrying around the under-developed legs and arms of what would have been his twin in a normal pregnancy.
But last summer, top doctors at the Fortis Hospital Bangalore agreed to operate on Deepak for free, as his parents, Indu and Veeresh, couldn't afford the whopping £50,000 it would have cost.
A team of six surgeons first cut away the extra limbs and then spent the final two hours sealing off the blood vessels Deepak shared with his twin.
The brave lad spent two weeks in hospital before being sent home. Today, the only reminder is a six-inch scar running from his rib cage to his stomach from where the twin was removed. 
Had he gone without surgery, Deepak's life would have been at risk due to the increased strain on his organs and frequent infections. The parasite even had its own intestines, which had to be taken away from Deepak's liver.
Speaking about the surgery, Deepak's mum, Indu, said she was incredibly nervous about the procedure:
'There was a major artery connecting Deepak to the twin, and if that had not been clipped properly, it would have put Deepak's life in danger. Me and his dad waited at the hospital while Deepak spent four hours in surgery. We sat hoping and praying that he would be okay.
'Once we found out he'd made it through, we were so relieved. All of the fear left us and suddenly all we could see was a brighter future for Deepak. He sometimes tells us that his father cut off the twin and threw it away in the fields, other than that, he hardly ever talks about it. He's too busy running around with his friends - he could never do that before as the twin weighed him down and he'd quickly get out of breath.'
Indu also explained that Deepak battled years of abuse about his condition, with some people suggesting he was possessed by the devil:
'People used to throw things at Deepak and I would hear all the whispers from neighbours, saying he was possessed by the devil. People told me he was a monster who would eat us.'
Deepak is completely healthy after the operation, and the only reminder is the scar across his tummy.
The little boy can now do everything he struggled with before his operation, saying:
'I can run faster than my two elder brothers - before I could never keep up. I really like my new body. It's much more fun. I am very happy.'
Lead surgeon at Fortis Hospital Bangalore, Dr Ramcharan Thiagrajan, said: 'This is a very rare phenomenon and only a small proportion of babies with parasitic twins live. We are very happy with the results.'

CASE DESCRIPTION:
A case of a seven-year-old Indian boy has caught the attention of the medical fraternity across the world for being a rare case in which his conjoined twin was attached to his abdomen. While imagining the actual figure of the boy with total eight limbs is hard to do, that's what the boy from Bihar had to face for years. 
The boy had no option but to bear the stigma of seeing scared eyes of people around him as he was called a devil by many. But a ray of hope was seen in the form of surgeons in Bangalore, who attempted a four hours long operation to remove the extra limbs. The boy has got a fresh lease of life with new body which he's certainly enjoying showing others who used to tease him earlier.
"This is a very rare phenomenon - only a small proportion of babies with parasitic twins live", said lead surgeon Dr. Ramcharan Thiagarajan, who performed the complicated operation for free.
Though the poor family tried their best to save the boy from emotional trauma, he had to go through it from the time of birth.
Now, the seven-year-old is enjoying the life of a normal boy and the credit goes to the leading surgeons from Bangalore's Fortis Hospital.
by
Akshaya Srikanth
Pharm.D Intern
Hyderabad, India

Made Easy 5 Minutes - ECG Interpretation

Electrocardiography (ECG or EKG) is a transthoracic interpretation of the electrical activity of the heart over time captured and externally recorded by skin electrodes. It is a noninvasive recording produced by an electrocardiographic device.
The ECG works by detecting and amplifying the tiny electrical changes on the skin that are caused when the heart muscle "depolarises" during each heart beat. During each heartbeat  heart will have an orderly progression of a wave of depolarisation that is triggered by the cells in the sinoatrial node, spreads out through the atrium, passes through "intrinsic conduction pathways" and then spreads all over the ventricles. This is detected as tiny rises and falls in the voltage between two electrodes placed either side of the heart which is displayed as a wavy line either on a screen or on paper.












Prepared and Presented by
Akshaya Srikanth, Dr. S.Chandra Babu*
Pharm.D Intern, *Asst.Prof of Medicine
RIMS Medical College, Kadapa
India

Pharm.D THE No.1 EMPLOYER IN PHARMA INDUSTRY

Many expect the Hospitals or Chain pharmacies (with reasonable pay) in India as the main anticipated employer of Pharm D graduates. And many are afraid that these job sectors are not yet pre-equipped for holding Pharm Ds in India.
Its wondering that the prime (No.1) sectors which need the service of Pharm.Ds are the pharmaceutical industries. They make new medicines and they need the professionals first than any other sector. Then the second priority comes to the hospitals of pharmacies where it is used or distributed.
Production is may be one among ten divisions of an industry where Pharm.Ds may not be needed. See the other nine where Pharm.D is the first choice for an Industry:
1. Clinical Research (for clinical trials - in thousands)
2. Pharmacovigilance (mandatory now for all companies - in thousands)
3. Research & Development (In hundreds)
4. Medical Writing (In hundreds)
5. Product Managers (In hundreds)
6. Regulatory affairs (In hundreds)
7. Correspondents & Trainers (In hundreds)
8. Top level medical representatives (In thousands)
9. Or more is your home work......

So I wish the Pharm.D aspirants not to worry about their future.. Lets learn the best to serve the best
by
Akshaya Srikanth Bhagavatula
Pharm.D* Internee
RIMS, Kadapa, A.P
India

Senin, 30 Januari 2012

FACTS ON COPD


Chronic bronchitis and emphysema are together called chronic obstructive pulmonary disease, or COPD. This is a chronic condition where not enough air enters or leaves the lungs.
In chronic bronchitis, the airways (or bronchi) that connect the windpipe and the lungs become inflamed and swollen. The airways become narrow and are clogged up with thick mucus, called phlegm. Chronic bronchitis may be found together with emphysema, in which destructive changes of the air sacs in the lungs cause them to become larger, reducing the surface area where oxygen exchange takes place. Both diseases make it difficult to breathe.
It's a very common condition, especially among people who smoke. More than 700,000 Indians have COPD. In the United States, about 12 million are affected with this condition. COPD is the fourth leading cause of death in both India, Canada and the United States. More women than men have COPD, except in the age category above 75.

Causes of Chronic Obstructive Pulmonary Disease (COPD)
Smoking is the main cause of COPD. It causes the airways to produce excess mucus that lines the walls of the airways, making the air passages very narrow. This makes it easier to get a bronchial infection. An infection can cause even more damage to the airways by causing more mucus production.
Less common causes of COPD include a rare genetic disorder called alpha-1 antitrypsin deficiency, air pollution, exposure to occupational dusts and chemicals, and frequent lower respiratory infections during childhood.

Symptoms and Complications of Chronic Obstructive Pulmonary Disease (COPD)
People with chronic bronchitis may cough up phlegm almost every day.
It is common for someone with chronic bronchitis to persistently cough and wheeze when breathing. It is also common to feel short of breath. Low oxygen in the blood due to the decreased ability to diffuse oxygen across the air sacs may cause the lips or fingernails to become bluish in colour.
COPD can lead to heart failure, as the heart has to work harder to pump blood into the lungs. When the heart fails to pump blood properly, it collects in the blood vessels of the legs and ankles and causes them to swell - this is called edema.
Sometimes you may become housebound because of breathing difficulties, even when doing simple tasks such as getting dressed or washing.
If you have COPD, it is likely that you may catch one or two infections every winter. You may also occasionally cough up blood. If this happens, it may be a sign of a more serious problem and it's important to see your doctor.

Diagnosing Chronic Obstructive Pulmonary Disease (COPD)
Clinicians will test to see how much air you can forcefully exhale in one second. Thesepulmonary, or lung breathing, tests are simple and painless. If you exhale less than normal, your airways are inflamed, in spasm, or clogged up with mucus. If this persists, then you may have COPD.

Treating and Preventing Chronic Obstructive Pulmonary Disease (COPD)
Even with treatment, COPD often becomes progressively worse. The only treatment to slow the progression of COPD is stopping smoking. Lung function deteriorates with age, and it happens much faster if you're a smoker.
Your doctor may prescribe medications called short-acting bronchodilators, including salbutamol*, ipratropium bromide, or a combination of the two, which relax and widen the bronchi and help relieve shortness of breath.
If symptoms are persistent, treatment with long-acting bronchodilators such as tiotropium, salmeterol, or formoterol can be added. If there is any inflammation present (not as common in COPD as in asthma), your doctor may suggest that you try inhaled or oral corticosteroids to help with breathing.
There are also medications available that combine long-acting bronchodilators with inhaled corticosteroids. Your doctor may also prescribe antibiotics for you to keep at home in case a bacterial lung infection develops.
Since influenza (the flu) may make COPD symptoms worse and can lead to respiratory failure, it is recommended that people with COPD receive the annual flu vaccine. Some people with COPD may also benefit from receiving a pneumococcal vaccine to lower their risk of getting pneumonia (lung infection), which can also lead to complications. Talk to your doctor about receiving these vaccines.
Inhaling oxygen from oxygen cylinders or an oxygen concentrator for least 15 hours a day may also be helpful for some people with COPD. Finally, drinking plenty of fluids throughout the day can help loosen phlegm buildup.
Exercise with or without a formal physiotherapy program can improve a person's quality of life and activities. A healthy nutritional intake is important, as weight loss due to the increased work of breathing presents a serious sign of advancing COPD. Lung reduction surgery or lung transplantation can also be considered in extreme cases.
by
Akshaya Srikanth, Dr.Chandra Babu*
Pharm.D Intern, Asst.Prof of Medicine
RIMS, Kadapa, A.P
INDIA

Diabetes and Cardiovascular Disease

At least 10.3 million Americans have been diagnosed with diabetes mellitus, and another 5.4 million are estimated to have undiagnosed diabetes.  Onset often precedes diagnosis by several years.
About 90% of diabetic patients have Type II diabetes 
Diabetes:   Type II Diabetes and Insulin Resistance
Type II diabetes is most common form, occurring later in life, and involving combination of impaired insulin-mediated glucose disposal (insulin resistance) and defective secretion of insulin by pancreatic beta cells
Insulin resistance develops from obesity and physical inactivity and insulin secretion declines with advancing age (and accelerated by genetic factors)
Diabetes and the Dysmetabolic Syndrome
Insulin resistance often precedes type II diabetes and is often accompanied by other risk factors-- dyslipidemia, hypertension, and prothrombotic factors, the “dysmetabolic syndrome”
Impaired fasting glucose (110-125 mg/dl) often accompanies the dysmetabolic syndrome.
The threshold for fasting plasma glucose for diagnosis of diabetes has been lowered from 140 mg/dl to 126 mg/dl.
Diabetes:  Complications
Cardiovascular diseases (CVD) account for about 65% of all deaths in diabetics; those with CVD have a worse prognosis than CVD patients without diabetes.
Complications include CHD, stroke, peripheral arterial disease, nephropathy, retinopathy, and possibly neuropathy and cardiomyopathy.
Stroke mortality 3-fold in diabetics vs. nondiabetics.    Carotid atherosclerosis and likelihood of irreverisible brain damage from stroke more common in diabetics. 
Renal impairment is a severe complication of diabetes; about 35% of pts with Type I diabetes have some renal impairment.  End stage renal disease (ESRD) carries a high mortality (20%/year in dialysis pts) and is more common in Hispanics, blacks, and Native Americans
Potential Mechanisms of Atherogenesis in Diabetes
Abnormalities in apoprotein and lipoprotein particle distribution
Glycosylation and advanced glycation of proteins in plasma and arterial wall
“Glycoxidation” and oxidation
Procoagulant state
Insulin resistance and hyperinsulinemia
Hormone-, growth-factor, and cytokine-enhanced SMC proliferation and foam cell formation
by
Akshaya Srikanth, Dr.S.Chandra Babu*
Pharm.D Intern, *Asso.Professor of Medicine,
RIMS, Kadapa
India

At your Pharmacy

Your visit to the pharmacy is an important but often unappreciated step in maintaining your health and that of your family. Consumers have a wide array of over-the-counter medications to choose from. Many of the medications now available without a prescription were previously available only after a visit or phone call to your health-care provider.
This open access to medications provides you with the ability to rapidly self-medicate a variety of common ailments. But the open access also exposes you to potential harm if you don't use such medications correctly. Before you take any medication, including herbals and dietary supplements, read the label. Make certain that you know what the medication is used for, what the dose is, what warnings exist and what side effects you may experience.
If you have any questions, speak with the pharmacist. Pharmacists are trained in drug therapy issues and can advise you on what over-the-counter medications may be best for you. People with chronic medical conditions such as high blood pressure or diabetes should not take some medications. Many over-the-counter medications, herbals and dietary supplements can interact with prescription medications. So it is important that you understand which medication is best and how to take it safely.
Much of the same advice holds true when you are picking up a prescription medication. The pharmacist needs to have a listing of all of your medications to check for medication interactions and to make certain that the medication prescribed is best for you.
Because many people see different health-care providers for different conditions, the pharmacist's role is very important to your safety. In many instances, the pharmacist may be the only person besides you who has a complete listing of the medications you take. It is also important that you make certain that the pharmacist knows about any medication allergies or food allergies you may have and any medication-related complications you may have had in the past. You should keep a list of all of the medications you take and all of the medication reactions you may have had, unless you can recall all of them quickly.

BE INQUISITIVE
You have an important role to play when you pick up your prescription at the pharmacy. Although very few people take advantage of the opportunity, you should always speak with the pharmacist when you start a new prescription. Taking a new medication is equivalent to an experiment. Although medical professionals know how medications work and how most people will respond, people are different because of their genetics, the disease they have and the other medications they take. So it is important that you know the answers to the following:
1) What is the name of the medication, and what strength are you taking?
You will need this information to add to your list of medications.
2) Why have you been prescribed this medication?
This information is important in case your health-care provider changes your medications for this condition. Many people suffer side effects because they mistakenly are taking several medications for the same condition.
3) How many doses should you take and when should you take them?
You may have to take several tablets or capsules to get the right dose for you, or you may have to take the medication several times a day. Many people get into trouble by either overdosing or underdosing.
4)What side effects do you need to watch for?
Many people who have suffered major side effects from medications could have prevented a serious event if they had recognized the early warning signs.
5) What should you do if you miss a dose?
What you should do is going to depend on the medication and why you are taking it. Some medications should be taken as soon as you remember, others should not be. There are instances when timing is important. For example, with some medications, if you remember you missed a dose six hours ago, you should still take the medication, but if you remember you missed a dose 12 hours ago, you should not. Your pharmacist can provide you with this information.
6) How long do you need to take the medication?
You should ask this question regardless of whether you are taking a medication for a short period of time, such as an antibiotic, or for life, such as high blood pressure medications. Many people do not take all of the doses of an antibiotic they have been prescribed. This can lead to incomplete treatment and, more importantly, to bacterial resistance to antibiotic therapy. If you are taking a medication for high blood pressure or diabetes, you should continue to take it until your health-care provider tells you to stop.
7) Do you need to avoid any foods or other medications while taking the medication?
Everyone probably knows that some medications should not be taken together, but did you know that there are some medications that should not be taken with certain foods? Grapefruit juice, for example, prevents some medications from being metabolized. Aged cheeses can precipitate what is called a hypertensive crisis (very high blood pressure and risk of stroke or heart attack) in people taking medications called monoamine oxidase inhibitors.

Although it happens rarely, pharmacies sometimes make mistakes and give out the wrong medication or the wrong dose of a medication. Pharmacies have many safeguards to make certain that your prescription is filled correctly, that you have the right medication at the right strength. And pharmacists are trained to dispense medications.
But unfortunately, errors can and do occur. So it is important to ask about any changes in your medications. If the color or shape of the tablet or capsule is different, ask.
by
Akshaya Srikanth*, S.K.Jain**
Pharm.D Intern, Chief Pharmacist, 
AIIMS, India

Minggu, 29 Januari 2012

Scientists Discover New Vaccine Approach To Treat Cancer


  • Scientists have discovered a new approach for treating cancer based on manipulating the immune response to malignant tumors.
  • And the team at Trinity College Dublin, Ireland, led by Professor Kingston Mills, Professor of Experimental Immunology, have also developed a new vaccine to treat cancer at the pre-clinical level. 
  • The discovery has been patented and there are plans to develop the vaccine for clinical use for cancer patients. 
  • The first cancer vaccine Sipuleucel-T (Provenge(tm)) was licensed last year for use in prostate cancer patients unresponsive to hormone treatment. 
  • Unfortunately, this cell-based vaccine only improves patient survival by an average of 4.1 months. 
  • Vaccines for infectious diseases are highly effective at generating immune responses that prevent infection with bacteria or viruses. The immune system can also protect us against tumors and in theory a vaccine approach should be effective against cancer. 
  • In practice this has proven very difficult because unlike infectious diseases, tumors are derived from normal human cells, and not made up of foreign substances or antigens capable of triggering an immune response. 
  • The tumors instead produce molecules that suppress the efficacy of the immune system. They generate regulatory cells that inhibit the immune response that could potentially clear the tumors. 
  • Professor Mills' group has developed a novel vaccine and immunotherapeutic approach that can overcome these obstacles and has the potential to significantly improve on existing technologies. 
  • The therapy is based on a combination of molecules that manipulates the immune response to curb the regulatory arm while enhancing the protective arm, allowing the induction of specialist white blood cell called killer T cells to target and eliminate the tumors. The new vaccine approach was found to be highly effective at pre-clinical stage in treating a range of cancers in murine models. 
The findings were published in December online in Cancer Research entitled
Original article: Effective treament of metastatic forms of Epstein-Barr virus-associated nasopharyngeal carcinoma with a novel adenovirus-based adoptive immunotherapy.
Authors: Corey Smith, Janice Tsang et.al 
Abstract
Nasopharyngeal carcinoma (NPC) is endemic in China and Southeast Asia where it is tightly associated with infections by Epstein-Barr virus (EBV). The role of tumor-associated viral antigens in NPC render it an appelaing candidate for cellular immunotherapy. In earlier preclinical studies, a novel adenoviral vector-based vaccine termed AdE1-LMPpoly has been generated that encodes EBV nuclear antigen-1 (E1) fused to multiple CD8+ T cell epitopes from the EBV latent membrane proteins LMP1 and LMP2. Here we report the findings of a formal clinical assessment of AdE1-LMPpoly as an immunotherapeutic tool for EBV-associated recurrent and metastatic NPC. From a total of 24 NPC patients, EBV-specific T cells were successfully expanded from 16 NPC patients (72.7%), while 6 NPC patients (27.3%) showed minimal or no expansion of virus-specific T cells. Transient increase in the frequencies of LMP1/2 and EBNA1-specific T cell responses was observed after adoptive transfer, associated with grade I flu-like symptoms and malaise. The time to progression (TTP) in these patients ranged from 38-420 days with a mean TTP of 136 days. Compared to patients who did not receive T cells, the median overall survival increased from 220 to 523 days. Taken together, our findings demonstrate that adoptive immunotherapy with AdE1-LMPpoly vaccine is safe and well tolerated and may offer clinical benefit to NPC patients.
by
Akshaya Srikanth
Pharm.D Internee
Hyderabad, India

Adverse drug reactions and medical and negligence

The tort [means a wrongful but not criminal activity ] of medical negligence is a breach of duty owed to a patient, with resulting harm. What is the 'duty of care' and who owes it? In legal terms we all owe a duty of care to our neighbour; in the medical field, for 'our neighbour' substitute 'our patient' and possibly the patient's dependants also, because harm to a patient may have repercussions on his dependants. In therapeutics the prescriber has a duty of care, but the chain of care stretches both backwards to the manufacturer and forwards to the pharmacist who dispenses and the nurse who administers the drug. Harm, then, may be caused at every stage of the therapeutic process from the development of the drug through to its clinical use. Where a direct connection between the drug and harm can be demonstrated on the balance of probabilities, the patient/plaintiff may be able to obtain compensation. The question of causation is sometimes difficult to resolve, and it is often helpful t o apply the test: " if the drug had not been used in this particular way, would the harm have occurred?" My article considers medico legal aspects of therapeutics, particularly with regard to adverse drug reactions and some of the case studies discussed relevantly.

1) THE DUTIES OF MANUFACTURER 
  • Before a drug can be licensed for use in patients, it must be tested. Date about adverse effects in humans may be relatively sparse at this stage; thus research using human subjects should be conducted according to a protocol that has been approved by an independent ethics committee, in accordance with the Declaration of Helsinki.1 Tests using human volunteers may not be covered by laws regulating medicines; for example, in the United Kingdom (UK) the Medicines Act 19682 does not deal with studies in healthy volunteers. However, they must be told of the risks they run in sufficient detail to enable them to give properly informed consent, particularly bearing in mind that there is no direct benefit, in health terms, to the subject.
CASE
A pharmaceutical company was convicted of issuing a false and misleading advertisement in the medical press, and their medical officer was convicted of consenting to and conniving with the issue of the advertisement.
Thirdly, there is the manufacturer's duty to warn of risk, 5,6 which may be achieved by the use of a patient information leaflet and/or a data sheet provided for prescribers, in which the manufacturer states what may be expected to be done with the product by a 'learned intermediary' (the prescriber), thus transferring a degree of responsibility to the prescriber.

2) THE DUTIES OF LICENCING AUTHORITY
  • A licensing authority has the responsibility to ensure that testing procedures for a product have been satisfactorily devised, implemented, and completed, the result reaching an acceptable standard before a product Licence is issued. A manufacturer who markets a product in accordance with a licensing standard may defend a claim if the standard set was wrong.
CASE 
The Irish Supreme Court decided recently that it had not been enough for vaccine manufacturers merely to comply with mandatory of minimum requirements, and that they had been negligent in releasing a batch of diphtheria, tetanus, and pertussis vaccine which by their own tests was of too high a potency and which had led to brain damage in infants. An authority, which requires reporting of adverse effects, has a duty to act on the information contained in such reports, perhaps revoking the product licence.

3) THE DUTIES OF PRESCRIBER
  • The potential prescriber should consider carefully whether a drug is needed for a particular patient. Is the benefit likely to outweigh the risk of possible adverse effects? Are there safer ways of achieving the same benefit? Are there reasons why this particular patient is more likely to suffer harm from adverse reactions of interactions?
CASE
A general practitioner was alleged to have prescribed a tranquillizer without warning the patient of possible side effects. The patient had taken two tablets and soon afterwards had driven a car and been involved in a road accident. The manufacturer's drug data sheet contained a warning against driving while under treatment with the drug. 'The patient was paid damages.
It may be necessary to obtain the agreement of the patient for routine monitoring of blood samples 

4) THE DUTIES OF PHARMACIST
  • As a professional, the pharmacist has a duty of care to the patient both to supervise the sale of 'over-the-counter' (OTC) drugs which are available only in pharmacies and to dispense safely and correctly drugs which have been prescribed by a doctor. OTC drugs may be unsuitable for an individual patient for a number of reasons. If approached for advice, the same duty lies on the pharmacist to counsel, warn, and act reasonably as it does on any prescriber. In addition, there is a duty to contact the prescriber if any question about a prescription arises. 

CASE 

A Doctor prescribed an antibiotic for a patient, but the pharmacist misread the very badly written prescription and wrongly dispensed an antidiabetic drug. The patient suffered severe hypoglycaemia and brain damage. The doctor's legal representative claimed that the pharmacist should have contacted the doctor and queried the does of 3 tablets 3 times daily (which would have been most unusual for the antidiabetic drug), but it was finally agreed that both the doctor and the pharmacist had been negligent.

5) DUTIES IN ADMINISTERING DRUGS
  • Just as care is needed in prescribing drugs, so is care needed in their administration. Knowledge of where to place an injection to order to avoid a nerve or other structure is expected of a practitioner, so that an error speaks for itself as a negligent act.
CASE

A patient was given a corticosteroid preparation by injection into the upper arm, although the manufacture's instructions stated clearly that the drug should only be given by deep intramuscular injection into the buttock, because of the danger of fat atrophy. The patient developed skin changes and loss of subcutaneous tissue, for which she successfully claimed compensation.

Errors in giving a drug by the wrong route can be catastrophic 

IMPORTANCE OF REPORTING ADVERSE DRUG REACTIONS
Adverse drug reactions very often produce symptoms of signs that may be difficult or impossible to distinguish from those of naturally occurring disorders. Consequently, doctors should never dismiss suspicions that a drug might have been responsible for a patient's illness merely because they think the evidence is flimsy. Instead, they should report their suspicions, however tenuous, to their national drug safety organization. They have a duty to make their observations known for they may be the first of their kind and may alert other doctors to the possibility of previously unrecognized adverse effects of treatment, and so protect patients against harm. The following are examples of reactions that should always be reported: anaphylaxis, blood dyscrasias, congenital abnormalities, endocrine disturbances, severe CNS effects, haemorrhage, jaundice, ophthalmic signs and symptoms, severe skin reactions. 
If my article is useful kindly share your comments and suggestions
by
Akshaya Srikanth, S.K.Jain*
Pharm.D Internee, *Chief Pharmacist-AIIMS
Hyderabad, India.

ORAL CONTRACEPTIVE PILLS

The combined oral contraceptive pill is a birth control method that includes a combination of an estrogen and a progestin.Combined oral contraceptive pills were developed to prevent ovulation by suppressing the release of gonadotropins. Combined hormonal contraceptives, including COCPs, inhibit follicular development and prevent ovulation as their primary mechanism of action.
Progestagen negative feedback decreases the pulse frequency of gonadotropin-releasing hormone (GnRH) release by the hypothalamus, which decreases the release of follicle-stimulating hormone (FSH) and greatly decreases the release of luteinizing hormone (LH) by the anterior pituitary. Decreased levels of FSH inhibit follicular development, preventing an increase in estradiol levels. Progestagen negative feedback and the lack of estrogen positive feedback on LH release prevent a mid-cycle LH surge. Inhibition of follicular development and the absence of a LH surge prevent ovulation.
Estrogen was originally included in oral contraceptives for better cycle control (to stabilize the endometrium and thereby reduce the incidence of breakthrough bleeding), but was also found to inhibit follicular development and help prevent ovulation. Estrogen negative feedback on the anterior pituitary greatly decreases the release of FSH, which inhibits follicular development and helps prevent ovulation.
Combined oral contraceptives may influence coagulation, increasing the risk of deep venous thrombosis (DVT) and pulmonary embolism, stroke and myocardial infarction. Combined oral contraceptives are generally accepted to be contraindicated in women with pre-existing cardiovascular disease, in women who have a familial tendency to form blood clots (such as familial factor V Leiden), women with severe obesity and/or hypercholesterolemia, and in smokers over age 40.And they are also contraindicated for women with Liver tumors, hepatic adenoma or severe cirrhosis of the liver, and for those with known or suspected breast cancer.
COC decrease the risk of ovarian cancer, endometrial cancer and colorectal cancer.
by
Akshaya Srikanth
Pharm.D Internee
Hyderabad, India

TOTAL PARENTERAL NUTRITION


Parenteral nutrition (PN) is feeding a person intravenously, bypassing the usual process of eating and digestion.It is called total parenteral nutrition (TPN) when no food is given by other routes.
Parenteral nutrition is provided when the gastrointestinal tract is nonfunctional because of an interruption in its continuity or because its absorptive capacity is impaired.It has been used for comatose patients, although enteral feeding is usually preferable, and less prone to complications. Indications: TPN may be the only feasible option for patients who do not have a functioning GI tract or who have disorders requiring complete bowel rest, such as the following: Some stages of Crohn's disease or ulcerative colitis, bowel obstruction, certain pediatric GI disorders, e.g., congenital GI anomalies, prolonged diarrhea regardless of its cause, or short bowel syndrome due to surgery.
Complications are either related to catheter insertion, or metabolic, including refeeding syndrome. Catheter complications include pneumothorax, accidental arterial puncture, and catheter-related sepsis.Metabolic complications include the refeeding syndrome characterised by hypokalemia, hypophosphatemia and hypomagnesemia. Hyperglycemia is common at the start of therapy, but can be treated with insulin added to the TPN solution. Hypoglycaemia is likely to occur with abrupt cessation of TPN. Liver dysfunction can be limited to a reversible cholestatic jaundice and to fatty infiltration.Also total parenteral nutrition increases the risk of acute cholecystitis due to complete unusage of gastrointestinal tract, which may result in bile stasis in the gallbladder.
by
Akshaya Srikanth
Pharm.D Intern
RIMS Hospital, Kadapa
India

Polycystic Ovary Syndrome: Characteristics and Clinical Controversies

Polycystic Ovarian Syndrome (PCOS) Overview: 

  • PCOS is a complex endocrine disorder affecting women of childbearing age characterized by increased androgen production and ovulatory dysfunction
  • PCOS is the leading cause of anovulatory infertility and hirsutism
  • Women with PCOS have an increased risk of miscarriage, insulin resistance, hyperlipidemia, type 2 diabetes, cardiovascular disease, and endometrial cancer

PCOS: National Institutes of Health Diagnostic Criteria 

  • Presence of ovulatory dysfunction, polymenorrhea, oligomenorrhea, or amenorrhea

Clinical evidence of hyperandrogenism and/or hyperandrogenemia

  • Exclusion of other endocrinopathies (eg, Cushing syndrome, hypothyroidism, late-onset congenital adrenal hyperplasia
  • May appear at puberty with a delayed menarche followed by the onset of irregular periods or as the breakdown of a previously regular cycle 
  • Anovulation is usually chronic and presents as oligomenorrhea or amenorrhea 

Clinical Features of PCOS - Hyperandrogenism

  • Symptoms may include hirsutism, acne, male pattern balding, and/or male distribution of body hair
  • Common Endocrine Abnormalities in PCOS
  • Elevated luteinizing hormone (LH)
  • Increased LH/follicle-stimulating hormone (FSH) ratio
  • Elevated androgen levels
  • Decreased sex hormone binding globulin levels 

Metabolic Abnormalities in PCOS

  • Hyperinsulinemia and insulin resistance
  • Insulin resistance may be independent of the effect of obesity
  • Decreased peripheral insulin sensitivity and consequent hyperinsulinemia may play an important role in the pathogenesis of PCOS

Lipid and Lipoprotein Abnormalities in PCOS

  • Elevated LDL cholesterol
  • Elevated triglycerides 
  • Decreased HDL cholesterol
  • Decreased apolipoprotein A-I
  • Impaired fibrinolytic activity

Etiology of PCOS
PCOS may be caused by interactions between

  • Genetic factors (eg, autosomal dominant transmission)
  • Endocrine factors (eg, increased LH/FSH ratio, increased insulin and androgen concentrations)
  • Metabolic factors (eg, increased insulin resistance,  decreased SHBG)
  • Neurologic factors (eg, epileptic discharges)
  • Environmental factors (eg, anabolic steroids) 

Developmental Origin of PCOS
During gestation, human chorionic gonadotrophin, LH, and genes regulating folliculogenesis and steroidogenesis may cause excess prenatal androgen
Postpubertally, hyperinsulinemia and LH hypersecretion augment ovarian steroidogenesis, leading to anovulation.
by
Akshaya Srikanth,
Pharm.D Internee,
Hyderabad, India

Sabtu, 28 Januari 2012

Pharmacological Management of Heart Failure


Treatment of Chronic Heart Failure aims to relieve symptoms, to maintain a euvolemic state (normal fluid level in the circulatory system), and to improve prognosis by delaying progression of heart failure and reducing cardiovascular risk. Drugs used include: diuretic agents, vasodilator agents, positive inotropes, ACE inhibitors, beta blockers, and aldosterone antagonists (e.g.spironolactone).
ACE inhibitor therapy is recommended for all patients with systolic heart failure, irrespective of symptomatic severity or blood pressure.ACE inhibitors improve symptoms, decrease mortality and reduce ventricular hypertrophy. Angiotensin II receptor antagonist therapy,particularly using candesartan, is an acceptable alternative if the patient is unable to tolerate ACEI therapy.
Diuretic therapy is indicated for relief of congestive symptoms. Several classes are used, with combinations reserved for severe heart failure:
* Loop diuretics (e.g. furosemide) – most commonly used class in CHF, usually for moderate CHF.
* Thiazide diuretics (e.g. hydrochlorothiazide) – may be useful for mild CHF, but typically used in severe CHF in combination with loop diuretics, resulting in a synergistic effect.
* Potassium-sparing diuretics (e.g.Spironolactone) – used first-line use to correct hypokalaemia.
As with ACEI therapy, the addition of a β-blocker can decrease mortality and improve left ventricular function. Several β-blockers are specifically indicated for CHF including: bisoprolol, carvedilol, nebivolol and extended-release metoprolol.
Digoxin (a mildly positive inotrope and negative chronotrope), once used as first-line therapy, is now reserved when the adequate control is not achieved with an ACEI, a beta blocker and a loop diuretic.There is no evidence that digoxin reduces mortality in CHF, although some studies suggest a decreased rate in hospital admissions.It is contraindicated in cardiac tamponade and restrictive cardiomyopathy.
by
Akshaya Srikanth,
Pharm.D Intern
RIMS Hospital, Kadapa
INDIA

Differential Diagnosis of Wide QRS Complex Tachycardia

-Ventricular tachycardia (about 80% of cases ).
-SVT with abnormal interventricular conduction (15-30 %):
*SVT with BBB aberration (fixed or functional).
*Pre-excited SVT (SVT with ventricular activation occurring over an anomalous AV connection ).Their ECG can be indistinguishable from VT originating at the base of ventricle.(1-5 % of all)
*SVT with wide QRS due to abnormal muscle-muscle spread of impulse.( surgery, DCM)
*SVT with wide complex due to drug or electrolyte-induced changes. (hyperkalemia. Class Ia ,Ic drugs or Amiodarone)
-Ventricular paced rhythms 
SVT vs VT 
-The majority of patients with VT have structural heart disease, In SVT they may or may not have.
-Patient with VT are older.
-Patients with SVT more often have history of previous similar episodes .
-Overall appearance of patient is not accurate.
-The widespread impression that hemodynamic stability indicates SVT is erroneous and can lead to dangerous mistreatment.
-Physical findings that indicate presence of AV dissociation (cannon A waves, variable-intensity S1,variation in BP unrelated to respiration) if present are useful.
-Termination of WCT in response to maneuvers like Valsalva, carotid sinus pressure, or adenosine is strongly in-favor of SVT but there are well-documented cases of VT responsive to these.
-Diagnostic injection of verapamil or beta-blockers should be discouraged. (prolonged hypotension).
-QRS duration:70% of VTs have QRS duration more than140, but no SVT has it. VT is probable when QRS  more than 140 with RBBB and more than160 with LBBB pattern.Anti arrhythmic drugs may prolong QRS. Some patients with VT may have QRS of 120-140 specially in those without structural heart disease.
by
Akshaya Srikanth, Dr.S.Chandra Babu*
Pharm.D*, *Asso.Professor of Medicine
RIMS Medical College, Kadapa, A.P
INDIA

LEARN ECG IN 5 MINUTES - A SIMPLE GUIDE TO ECG



Normal P waves 
Height less than 2.5 mm in lead II 
Width less than 0.11 s in lead II 
Abnormal P waves see in right atrial hypertrophy, left atrial hypertrophy, atrial premature beat, hyperkalaemia

Normal PR interval 
0.12 to 0.20 s (3 - 5 small squares) 
Short PR segment consider Wolff-Parkinson-White syndrome or Lown-Ganong-Levine syndrome (other causes - Duchenne muscular dystrophy, type II glycogen storage disease (Pompe's), HOCM) 
Long PR interval see first degree heart block and 'trifasicular' block 

Normal QRS complex 
Less than 0.12 s duration (3 small squares) 
for abnormally wide QRS consider right or left bundle branch block, ventricular rhythm, hyperkalaemia, etc.
no pathological Q waves 

Normal QT interval 
Calculate the corrected QT interval (QTc) by dividing the QT interval by the square root of the preceeding R - R interval. Normal = 0.42 s. 
Causes of long QT interval 
Myocardial infarction, myocarditis, diffuse myocardial disease 
Hypocalcaemia, hypothyrodism 
Subarachnoid haemorrhage, intracerebral haemorrhage 
Drugs (e.g. sotalol, amiodarone) 
Hereditary - Romano Ward syndrome (autosomal dominant) ,Jervill + Lange Nielson syndrome (autosomal recessive) associated with sensorineural deafness 

Normal ST segment  - no elevation or depression 
Causes of elevation include acute MI (e.g. anterior, inferior), left bundle branch block, normal variants (e.g. athletic heart, Edeiken pattern, high-take off), acute pericarditis 
cCauses of depression include myocardial ischaemia, digoxin effect, ventricular hypertrophy, acute posterior MI, pulmonary embolus, left bundle branch block 

Normal T wave 
Causes of tall T waves include hyperkalaemia, hyperacute myocardial infarction and left bundle branch block 
Causes of small, flattened or inverted T waves are numerous and include ischaemia, age, race, hyperventilation, anxiety, drinking iced water, LVH, drugs (e.g. digoxin), pericarditis, PE, intraventricular conduction delay (e.g. RBBB)and electrolyte disturbance.
Please share your comments & suggestions
by
Akshaya Srikanth, Dr.Chandra Babu*
Pharm.D Internee, *Asso.Professor of Medicine
RIMS Medical college, Kadapa.